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ABT-418 hydrochloride

カタログ番号GC60549

ABT-418 塩酸塩は、認知機能の向上と抗不安作用を持つ nAChR の強力かつ選択的なアゴニストです。

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ABT-418 hydrochloride 化学構造

Cas No.: 147388-83-8

サイズ 価格 在庫数 個数
5mg
$111.00
在庫あり
10mg
$185.00
在庫あり
25mg
$371.00
在庫あり
50mg
$556.00
在庫あり
100mg
$788.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of ABT-418 hydrochloride

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1].Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1].ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2].ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2]. Animal Model: Male SHRs (4-5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2]

[1]. Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271(1):353-61. [2]. Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528(1):11-5.

Chemical Properties of ABT-418 hydrochloride

Cas No. 147388-83-8 SDF
Canonical SMILES CN1[C@H](C2=CC(C)=NO2)CCC1.Cl
Formula C9H15ClN2O M.Wt 202.68
溶解度 H2O : 11.9 mg/mL (58.71 mM; Need ultrasonic) Storage 4°C, away from moisture
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of ABT-418 hydrochloride

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1 mg 5 mg 10 mg
1 mM 4.9339 mL 24.6694 mL 49.3389 mL
5 mM 0.9868 mL 4.9339 mL 9.8678 mL
10 mM 0.4934 mL 2.4669 mL 4.9339 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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