Acebilustat (Synonyms: CTX-4430) |
| カタログ番号GC19018 |
アセビルスタット (CTX-4430) は、ロイコトリエン A4 加水分解酵素阻害剤で、経口抗炎症薬に使用されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 943764-99-6
Sample solution is provided at 25 µL, 10mM.
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Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug.
Acebilustat is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1 trial[1]. Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils[2].
References:
[1]. Elborn JS, et al. Phase 1 Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Clin Transl Sci. 2016 Nov 2.
[2]. Elborn JS, et al. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin Transl Sci. 2016 Oct 28.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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