Acumapimod (Synonyms: BCT-197) |
| カタログ番号GC19019 |
Acumapimod (BCT197) は、経口で活性な p38 MAP キナーゼ阻害剤であり、p38α の IC50 は 1 μM 未満です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 836683-15-9
Sample solution is provided at 25 µL, 10mM.
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Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α.
Acumapimod is an inhibitor of p38α with an IC50 value of less than 1 uM.
BCT197 is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions, including chronic obstructive pulmonary disease (COPD). Intermittent short-term dosing of BCT197 (75 mg on days 1 and 6) shows a marked improvement in lung function in COPD patients[2].
References:
[1]. Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92.
[2]. De Buck S, et al. Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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