(+/-)-ADX 71743 |
| カタログ番号GC50245 |
mGlu7受容体の負のアロステリック調節因子；脳内浸透性
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Cas No.: 1431641-29-0
Sample solution is provided at 25 µL, 10mM.
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Negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.
Klar et al (2015) Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 35 7600 PMID:25972184 |Tassin et al (2016) Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network. Front Neural Circuits 10 31 PMID:27199672
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