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AG-183 (Synonyms: Tyrphostin 51)

カタログ番号GC14890

AG-183 はラノコナゾール A51 の Z 配置です。

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AG-183 化学構造

Cas No.: 122520-90-5

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5mg
$56.00
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10mg
$106.00
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25mg
$249.00
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50mg
$440.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

AG-183, a member of tyrphostin, is an inhibitor of protein tyrosine kinase [1].

Protein tyrosine kinase is an enzyme that catalyzes the transfer of the γ phosphate of ATP to tyrosine residues on protein substrates. Phosphorylation of proteins by kinases is an important mechanism in signal transduction and regulating cellular activity, such as cell division. Tyrosine phosphorylation is a key covalent modification that occurs in multicellular organisms as a result of intercellular communication during embryogenesis and maintenance of adult tissues. Phosphorylation of tyrosine residues modulates enzymatic activity and creates binding sites for the recruitment of downstream signaling proteins [2].

PTK inhibitors could preferentially inhibit the epidermal growth factor (EGF) receptor kinase to block EGF-dependent cell proliferation [1]. In the human epidermoid carcinoma cell line, A431AG-183 inhibited the activity of epidermal growth factor (EGF) receptor kinase with an IC50 value of 800 nM [1].

References:
[1] Gazit A, Yaish P, Gilon C, et al.  Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors[J]. Journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] Hubbard S R, Till J H.  Protein tyrosine kinase structure and function[J]. Annual review of biochemistry, 2000, 69(1): 373-398.

Chemical Properties

Cas No. 122520-90-5 SDF
同義語 Tyrphostin 51
Chemical Name 2-amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile
Canonical SMILES OC1=C(O)C(O)=CC(/C=C(C#N)/C(N)=C(C#N)\C#N)=C1
Formula C13H8N4O3 M.Wt 268.2
溶解度 ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.7286 mL 18.6428 mL 37.2856 mL
5 mM 0.7457 mL 3.7286 mL 7.4571 mL
10 mM 0.3729 mL 1.8643 mL 3.7286 mL
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