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AKT-IN-6

カタログ番号GC62190

AKT-IN-6(実施例13)は強力なAkt阻害剤である。 AKT-IN-6 は、Akt1、Akt2、および Akt3 をそれぞれ IC50 < 500nM で阻害します。 (特許WO2013056015A1)。

Products are for research use only. Not for human use. We do not sell to patients.

AKT-IN-6 化学構造

Cas No.: 1430056-54-4

サイズ 価格 在庫数 個数
5 mg
$108.00
在庫あり
10 mg
$189.00
在庫あり
25 mg
$378.00
在庫あり
50 mg
$648.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

顧客レビュー

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).

Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].

[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1.
[2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.

Chemical Properties

Cas No. 1430056-54-4 SDF
Formula C22H20FN5O M.Wt 389.43
溶解度 DMSO : 125 mg/mL (320.98 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.5679 mL 12.8393 mL 25.6786 mL
5 mM 0.5136 mL 2.5679 mL 5.1357 mL
10 mM 0.2568 mL 1.2839 mL 2.5679 mL
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計算

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for AKT-IN-6

Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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