Akt Inhibitor IV |
| カタログ番号GC42759 |
Akt阻害剤IVは、Akt活性化の阻害剤であり、Forkhead box class O転写因子1a（FOXO1a; IC50 = 625 nM）のAkt介在性核外移行を抑制し、Ser473およびThr308におけるAktのリン酸化を用量依存的に減少させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 681281-88-9
Sample solution is provided at 25 µL, 10mM.
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Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner. Akt inhibitor IV inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC50 = 520 nM). It also reduces the growth of cancer cells (IC50 = 0.3 μM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ROS).
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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