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ALK2-IN-2

カタログ番号GC65294

ALK2-IN-2 は、アクチビン受容体様キナーゼ 2 (ALK2) の強力かつ選択的な阻害剤であり、IC50 は 9 nM で、ALK3 に対して 700 倍以上の選択性があります。

Products are for research use only. Not for human use. We do not sell to patients.

ALK2-IN-2 化学構造

Cas No.: 2254409-25-9

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$344.90
在庫あり
5mg
$315.00
在庫あり
10mg
$495.00
在庫あり
25mg
$891.00
在庫あり
50mg
$1,485.00
在庫あり
100mg
$2,025.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

顧客レビュー

カスタマーレビューに基づきます。

  • GlpBio Citations

    GlpBio Citations
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3[1].

[1]. Jiang JK, et al. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3356-3362.

Chemical Properties

Cas No. 2254409-25-9 SDF Download SDF
Formula C28H27N5O2S M.Wt 497.61
溶解度 DMSO : 125 mg/mL (251.20 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.0096 mL 10.048 mL 20.0961 mL
5 mM 0.4019 mL 2.0096 mL 4.0192 mL
10 mM 0.201 mL 1.0048 mL 2.0096 mL
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**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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