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Amiodarone HCl

カタログ番号GC11432

ベンゾフランベースのクラス III 抗不整脈薬であるアミオダロン HCl は、~45 nM の IC50 で WT の外側の IhERG テールを阻害します。

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Amiodarone HCl 化学構造

Cas No.: 19774-82-4

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$41.00
在庫あり
50mg
$33.00
在庫あり
100mg
$82.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Amiodarone HCl is an anti-arrhythmic drug [1].

Amiodarone HCl has shown a non-competitive inhibition of the chronotropic effect of isoproterenol with a pD’ value of ~4.17. In addition, Amiodarone HCl has been reported to inhibit the norepinephrine-induced contractions in a non-competitive type with a pD’ value of about 4.06. Besides, all the results have been suggested that Amiodarone HCl does not compete with the agonists at their respective recognition sites. Amiodarone HCl has been found to be a different antagonizes types of anonists: β1-adrenergic agonists like isoproterenol, α-adrenergic agonists like norepinephrine and glucagon. Apart from these, Amiodarone HCl has exhibited tissular specificity. The adrenergic (glucagon) antagonism has been shown only on the heart and the arteries. Amiodarone HCl has noted no cpinephrine-induced lipolysis of the epididymal fat pad [1].

References:
[1] Polster P, Broekhuysen J. The adrenergic antagonism of amiodarone. Biochem Pharmacol. 1976 Jan 15;25(2):131-4.

Chemical Properties

Cas No. 19774-82-4 SDF
Chemical Name (2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone;hydrochloride
Canonical SMILES CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I.Cl
Formula C25H30ClI2NO3 M.Wt 681.77
溶解度 ≥ 13.8mg/mL in DMSO with gentle warming Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.4668 mL 7.3339 mL 14.6677 mL
5 mM 0.2934 mL 1.4668 mL 2.9335 mL
10 mM 0.1467 mL 0.7334 mL 1.4668 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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