Artemisinin-d3 (Synonyms: Qinghaosu-d3; NSC 369397-d3) |
| カタログ番号GC46882 |
アルテミシニンの定量化のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 176652-07-6
Sample solution is provided at 25 µL, 10mM.
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Artemisinin-d3 is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity.1,2 It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg.1,3 It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day).4 Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner.2 It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.
1.Akoachere, M., Buchholz, K., Fischer, E., et al.In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisininsAntimicrob. Agents Chemother.49(11)4592-4597(2005) 2.Zhu, S., Liu, W., Ke, X., et al.Artemisinin reduces cell proliferation and induces apoptosis in neuroblastomaOncol. Rep.32(3)1094-1100(2014) 3.Robert, A., Benoit-Vical, F., Claparols, C., et al.The antimalarial drug artemisinin alkylates heme in infected miceProc. Natl. Acad. Sci. U.S.A.102(38)13676-13680(2005) 4.Chawira, A.N., Warhurst, D.C., Robinson, B.L., et al.The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in miceTrans. R. Soc. Trop. Med. Hyg.81(4)554-558(1987)
| Cas No. | 176652-07-6 | SDF | |
| 同義語 | Qinghaosu-d3; NSC 369397-d3 | ||
| Canonical SMILES | [H][C@]12[C@@H](C([2H])([2H])[2H])C(O[C@@]3([H])[C@@]1(OO4)[C@](CC[C@]4(C)O3)([H])[C@H](C)CC2)=O | ||
| Formula | C15H19D3O5 | M.Wt | 285.4 |
| 溶解度 | DMSO: Slightly soluble,Methanol: Slightly soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.5039 mL | 17.5193 mL | 35.0385 mL |
| 5 mM | 0.7008 mL | 3.5039 mL | 7.0077 mL |
| 10 mM | 0.3504 mL | 1.7519 mL | 3.5039 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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