Artepillin C (Synonyms: 3,5-Diprenyl-4-hydroxy Cinnamic Acid,3,5-Diprenyl-p-hydroxy Cinnamic Acid,3,5-Diprenyl-para-hydroxy Cinnamic Acid,3,5-Diprenyl-4-Coumaric Acid,3,5-Diprenyl-p-Coumaric Acid,3,5-Diprenyl-para-Coumaric Acid) |
| カタログ番号GC91675 |
Artepillin C is a prenylated cinnamic acid that has been found in B. grisebachii and has diverse biological activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72944-19-5
Sample solution is provided at 25 µL, 10mM.
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Artepillin C is a prenylated cinnamic acid that has been found in B. grisebachii and has diverse biological activities.1,2,3,4,5,6 It selectively inhibits aldo-keto reductase 1C3 (AKR1C3; IC50 = 1 µM), also known as prostaglandin F synthase, over AKR1C1, AKR1C2, and AKR1C4 at 100 µM.[1] It also inhibits lipid peroxidation in isolated human erythrocytes.[2] Artepillin C (10 µM) induces calcium influx in HEK293T cells expressing human transient receptor potential ankyrin 1 (TRPA1), an effect that can be blocked by the TRPA1 inhibitor HC-030031 .[3] It is cytotoxic to HT-1080 fibrosarcoma and 26-L5 colon cancer cells (IC50s = 45.47 and 59.32 µg/ml, respectively).[4] Artepillin C is active against C. albicans, E. floccosum, T. rubrum, methicillin-sensitive S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 250, 50, 125, 250, and 250 µg/ml, respectively).[5] In vivo, artepillin C (1 and 10 mg/kg) decreases carrageenan-induced peritoneal leukocyte infiltration in mice.[6]
References:
[1].Endo, S., Matsunaga, T., Kanamori, A., et al.Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolisJ. Nat. Prod.75(4)716-721(2012).
[2].Tapia, A., Rodriguez, J., Theoduloz, C., et al.Free radical scavengers and antioxidants from Baccharis grisebachiiJ. Ethnopharmacol.95(2-3)155-161(2004).
[3].Hata, T., Tazawa, S., Ohta, S., et al.Artepillin C, a major ingredient of Brazilian propolis, induces a pungent taste by activating TRPA1 channelsPLoS One7(11)e48072(2012).
[4].Banskota, A.H., Tezuka, Y., Prasain, J.K., et al.Chemical constituents of brazilian propolis and their cytotoxic activitiesJ. Nat. Prod.61(7)896-900(1998).
[5].Feresin, G.E., Tapia, A., Gimenez, A., et al.Constituents of the Argentinian medicinal plant Baccharis grisebachii and their antimicrobial activityJ. Ethnopharmacol.89(1)73-80(2003).
[6].Paulino, N., Abreu, S.R., Uto, Y., et al.Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolisEur. J. Pharmacol.587(1-3)296-301(2008).
| Cas No. | 72944-19-5 | SDF | |
| 同義語 | 3,5-Diprenyl-4-hydroxy Cinnamic Acid,3,5-Diprenyl-p-hydroxy Cinnamic Acid,3,5-Diprenyl-para-hydroxy Cinnamic Acid,3,5-Diprenyl-4-Coumaric Acid,3,5-Diprenyl-p-Coumaric Acid,3,5-Diprenyl-para-Coumaric Acid | ||
| Formula | C19H24O3 | M.Wt | 300.4 |
| 溶解度 | Acetonitrile: Soluble,DMSO: Soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.3289 mL | 16.6445 mL | 33.2889 mL |
| 5 mM | 0.6658 mL | 3.3289 mL | 6.6578 mL |
| 10 mM | 0.3329 mL | 1.6644 mL | 3.3289 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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