Aurothioglucose (hydrate) (Synonyms: Gold Thioglucose) |
| カタログ番号GC49646 |
TrxR阻害剤
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Aurothioglucose is an inhibitor of thioredoxin reductase (TrxR; IC50 = 0.065 µM for the human placental enzyme).1 It is selective for TrxR over glutathione reductase and glutathione peroxidase (GPX; IC50s = >100 and 80 µM, respectively). Aurothioglucose (100 µM) inhibits IL-1β-induced production of IL-6 and IL-8 in isolated human rheumatoid synovial fibroblasts.2 It reduces HIV-1 replication induced by TNF-α in OM10.1 cells latently infected with HIV-1 when used at concentrations of 10 and 25 µM.3 Aurothioglucose (25 mg/kg) improves survival in a mouse model of acute respiratory distress syndrome (ARDS) induced by LPS and hyperoxia.4 It induces obesity and increases food intake and blood glucose levels in genetically diabetic KK mice.5 Formulations containing aurothioglucose have previously been used in the treatment of rheumatoid arthritis.
1.Gromer, S., Arscott, L.D., Williams, C.H., Jr., et al.Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady kinetics, and inhibition by therapeutic gold compoundsThe Journal of Biological Chemisty273(32)20096-20101(1998) 2.Yoshida, S., Kato, T., Sakurada, S., et al.Inhibition of IL-6 and IL-8 induction from cultured rheumatoid synovial fibroblasts by treatment with aurothioglucoseInt. Immunol.11(2)151-158(1999) 3.Traber, K.E., Okamoto, H., Kurono, C., et al.Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-α-induced HIV-1 replication in latently infected OM10.1 and Ach2 cellsInt. Immunol.11(2)143-150(1999) 4.Britt, R.D., Jr., Velten, M., Locy, M.L., et al.The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndromeAntioxid. Redox Signal.20(17)2681-2691(2014) 5.Matsuo, T., and Shino, A.Induction of diabetic alterations by goldthioglucose-obesity in KK,ICR and C57BL miceDiabetologia8(6)391-397(1972)
| Cas No. | N/A | SDF | |
| 同義語 | Gold Thioglucose | ||
| Canonical SMILES | O[C@@H]([C@@H]1O)[C@]([OH][Au+][S-]2)([H])C2O[C@@H]1CO.O | ||
| Formula | C6H11AuO5S • XH2O | M.Wt | 392.2 |
| 溶解度 | DMSO: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5497 mL | 12.7486 mL | 25.4972 mL |
| 5 mM | 0.5099 mL | 2.5497 mL | 5.0994 mL |
| 10 mM | 0.255 mL | 1.2749 mL | 2.5497 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >80.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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