Avobenzone-13C-d3 (Synonyms: BMDBM-13C-d3, Butyl Methoxydibenzoylmethane-13C-d3) |
| カタログ番号GC48771 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2933758-47-3
Sample solution is provided at 25 µL, 10mM.
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Avobenzone-13C-d3 is intended for use as an internal standard for the quantification of avobenzone by GC- or LC-MS. Avobenzone is a full-spectrum ultraviolet A (UVA) blocker.1 It inhibits UVA-induced increases in melanin levels and tyrosinase activity in B16/F10 melanoma cells (IC30s = 21.94 and 24.25 μM, respectively).2 Avobenzone (30 μM) also inhibits UVA-induced production of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine , as well as inhibits UVA-induced depletion of glutathione (GSH), in B16/F10 cells. It increases nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulates the antioxidant response element (ARE) in UVA-irradiated B16/F10 cells when used at at a concentration of 30 μM. Formulations containing avobenzone have been used as sun protectants in sunscreen products.
1.Beasley, D.G., and Meyer, T.A.Characterization of the UVA protection provided by avobenzone, zinc oxide, and titanium dioxide in broad-spectrum sunscreen productsAm. J. Clin. Dermatol.11(6)413-421(2010) 2.Chaiprasongsuk, A., Onkoksoon, T., Pluemsamran, T., et al.Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responsesRedox Biol.879-90(2016)
| Cas No. | 2933758-47-3 | SDF | |
| 同義語 | BMDBM-13C-d3, Butyl Methoxydibenzoylmethane-13C-d3 | ||
| Canonical SMILES | CC(C)(C)C1=CC=C(C(CC(C2=CC=C(O[13C]([2H])([2H])[2H])C=C2)=O)=O)C=C1 | ||
| Formula | C19[13C]H19D3O3 | M.Wt | 314.4 |
| 溶解度 | Acetonitrile: soluble,DMF: soluble,DMSO: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1807 mL | 15.9033 mL | 31.8066 mL |
| 5 mM | 0.6361 mL | 3.1807 mL | 6.3613 mL |
| 10 mM | 0.3181 mL | 1.5903 mL | 3.1807 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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