AZD3458 |
| カタログ番号GC65149 |
AZD3458 は、PI3Kγ、PI3Kα、PI3Kβ、および PI3Kδ に対してそれぞれ 9.1、5.1、<4.5、および 6.5 の pIC50 を持つ、強力で非常に選択的な PI3Kγ 阻害剤です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2132961-46-5
Sample solution is provided at 25 µL, 10mM.
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AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].
AZD3458 (Compound 15) also inhibits PI3KC2α, PI3KC2β, PI3KC2γ, and PI3KC3 with pIC50s of <5, 7.5, 5.5, and 5.1, respectively[1].
[1]. Pemberton N, et al. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors. J Med Chem. 2018 Jun 28;61(12):5435-5441.
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