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BIBF0775

カタログ番号GC34493

BIBF0775 は、34 nM の IC50 を持つ、強力かつ選択的なトランスフォーミング増殖因子 β (TGFβ) タイプ I 受容体 (Alk5) 阻害剤です。

Products are for research use only. Not for human use. We do not sell to patients.

BIBF0775 化学構造

Cas No.: 334951-90-5

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$136.00
在庫あり
5mg
$124.00
在庫あり
10mg
$193.00
在庫あり
50mg
$585.00
在庫あり
100mg
$945.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

顧客レビュー

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

BIBF0775 is a potent and selective transforming growth factor β (TGFβ) type I receptor (Alk5) inhibitor with an IC50 of 34 nM. IC50: 34 nM (Alk5)[1]

[1]. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI). J Med Chem. 2010 Oct 28;53(20):7287-95.

Chemical Properties

Cas No. 334951-90-5 SDF
Canonical SMILES O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(C3=CC=CC=C3)\NC4=CC=C(CN5CCCCC5)C=C4)N(CC)C
Formula C31H34N4O2 M.Wt 494.63
溶解度 DMSO : 62.5 mg/mL (126.36 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.0217 mL 10.1086 mL 20.2171 mL
5 mM 0.4043 mL 2.0217 mL 4.0434 mL
10 mM 0.2022 mL 1.0109 mL 2.0217 mL
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**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

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Average Rating: 5 ★★★★★ (Based on Reviews and 40 reference(s) in Google Scholar.)

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