Introduction: RSM-932A, also known as TCD- 717, is a ChoKα asset, which targets the mortal choline kinase nascence, an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A appears to have an altogether new medium of inhibition and is synergistic with respect to both choline and ATP. RSM-932A have in vitro inhibitory exertion in the low nanomolar range.

フェロトーシス（Ferroptosis）の発案者であるBrent R. Stockwellが、フェロトーシス10周年を記念して研究の進展に関するレビューを執筆し、科学術誌『Cell』（インパクトファクター66.85（2022年））に掲載されました。

前号では、薬物の溶解に関する処方や戦略を紹介しました。その中で、溶媒としてあんまり推奨されていないDMSOは共溶媒として知られていますが、かなり議論されています。DMSOは広く普及しており、強い毒性を持つことで、その使用がFDAによって制限されています。では、その毒性はどの程度なのか、実験ではどのように使用すればよいのか。

動物実験では、経口、腹腔内、静脈内、脳内注射など、さまざまな投与方法があります。しかし、私たちはその理由を知らずに、研究室で一般的な投与方法を選択してしまうことが多いです。例えば、我々の研究室では腹腔内注射を選択することが多いが、周りの人がその理由についてあまり知らないです。実際、その中には多くの知識が含まれています！今回は、薬理学・薬物動態学の観点から、投与方法の選択について一般的な原則を紹介します。

The sodium salt of palmitic acid, sodium palmitate ( Hexadecanoic acid sodium salt, Palmitic acid sodium salt) , produced during the process of fatty acid synthesis present in fats and waxes. It is produced synthetically and driven by palm oil. Plays major role as an emulsifier.

Brent R. Stockwell, the author of the origin of Ferroptosis, has written a review about research progress for the 10th anniversary of Ferroptosis, published in the journal Cell with a high impact factor of 66.85 (2022). The National Nature Foundation projects and the amount of money winning the bid in this direction are rising year by year, and the relevant research papers are also repeatedly topping the CNS! (Figure 1)

Alisol B (ALB), a triterpenoid compound extracted from Alisma, has been reported to ameliorate nonalcoholic steatohepatitis (NASH) and slow obesity.

Semaglutide is a polypeptide composed of 31 amino acids related by peptide bonds, with a molecular heaviness of 4114 g/mol. It actions as an agonist for glucagon-like peptide-1 receptors (GLP-1 R) and is functioned in the action of type 2 diabetes. Semaglutide purposes as a hypoglycemic agent, a GLP-1 receptor agonist, an anti-obesity mediator, a neuroprotective mediator, and want for food suppressant.

20-Hydroxyeicosatetraenoic acid (20-HETE) manufactured by forward thinkers Glpbio having Molecular Formula: C20H32O3 and Molecular Weight: 320.5 g/mol , is a remarkable arachidonic acid metabolite, playing a key role in many physiological and pathological activities.It is a quantitative and analytical standard that is guaranteed to meet the MaxSpec identity, purity, stability and concentration specifications.

SP2509 also known as HCI-2509 is a small low molecular weight organic compound that can enter into cells and interact with the biological targets .It is used as research tool to study various diseases and biological processes including cancer , inflammation and neurological disorders .