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BPIQ-II (hydrochloride) (Synonyms: PD 158294)

カタログ番号GC42968

BPIQ-IIは、表皮成長因子受容体(EGFR;IC50 = 8 pM)のチロシンキナーゼ活性を強力に阻害するリニアイミダゾロキナゾリンです。

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BPIQ-II (hydrochloride) 化学構造

Cas No.: 171179-37-6

サイズ 価格 在庫数 個数
500μg
$170.00
在庫あり
1mg
$305.00
在庫あり
5mg
$1,188.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

BPIQ-IIは、表皮成長因子受容体(EGFR;IC50 = 8 pM)のチロシンキナーゼ活性を強力に阻害するリニアーイミダゾロキナゾリンです。他のチロシンおよびセリン/スレオニンキナーゼのアッセイに対してEGFRに選択的です。細胞研究では、BPIQ-IIが細胞内に入り、ATPサイトで競合的に結合することでEGF刺激信号伝達を非常に選択的に停止させることが示されています。

Chemical Properties

Cas No. 171179-37-6 SDF
同義語 PD 158294
Canonical SMILES BrC1=CC(NC2=NC=NC3=C2C=C(NC=N4)C4=C3)=CC=C1.Cl
Formula C15H10BrN5•HCl M.Wt 376.6
溶解度 DMF: 10 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.6553 mL 13.2767 mL 26.5534 mL
5 mM 0.5311 mL 2.6553 mL 5.3107 mL
10 mM 0.2655 mL 1.3277 mL 2.6553 mL
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計算

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

Review for BPIQ-II (hydrochloride)

Average Rating: 5 ★★★★★ (Based on Reviews and 34 reference(s) in Google Scholar.)

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