C24 Phytosphingosine (t18:0/24:0) (Synonyms: Ceramide (t18:0/24:0), Cer(t18:0/24:0), C24:0 Phytoceramide, N-Lignoceroyl Phytosphingosine, NTetracosanoyl Phytosphingosine) |
| カタログ番号GC43076 |
C24フィトスフィンゴシン（t18：0 / 24：0）は、哺乳類表皮の角層細胞外空間、腸、腎臓に存在するスフィンゴリピドファミリーであるフィトセラミドの一種です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 34437-74-6
Sample solution is provided at 25 µL, 10mM.
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C24 Phytosphingosine (t18:0/24:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C24 Phytosphingosine (t18:0/24:0) is composed of a phytosphingosine backbone amine-linked to a C24 fatty acid chain. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro. In a stratum corneum model of healthy skin, the incorporation of long-chain-containing phytoceramides, such as C24 phytosphingosine (t18:0/24:0), increases permeability of the membrane in comparison with incorporation of dihydroceramides.
| Cas No. | 34437-74-6 | SDF | |
| 同義語 | Ceramide (t18:0/24:0), Cer(t18:0/24:0), C24:0 Phytoceramide, N-Lignoceroyl Phytosphingosine, NTetracosanoyl Phytosphingosine | ||
| Canonical SMILES | OC[C@H](NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O | ||
| Formula | C42H85NO4 | M.Wt | 668.1 |
| 溶解度 | Chloroform:Methanol (5:1): soluble | Storage | Store at -20°C; protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.4968 mL | 7.4839 mL | 14.9678 mL |
| 5 mM | 0.2994 mL | 1.4968 mL | 2.9936 mL |
| 10 mM | 0.1497 mL | 0.7484 mL | 1.4968 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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