Cafestol |
| カタログ番号GC40352 |
コーヒーの主要成分の 1 つである Cafestol は、コーヒー固有のジテルペンです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 469-83-0
Sample solution is provided at 25 µL, 10mM.
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Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1].
References:
[1]. Shen T, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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