Carboxylesterase-IN-3 |
| カタログ番号GC65167 |
カルボキシルエステラーゼ－ＩＮ－３（化合物４ｙ）は、１０ｎＭ以下のＩＣ５０を有するカルボキシルエステラーゼ ノタムの強力な阻害剤である。 Notum は、Wnt 活性に必要なパルミトレイン酸エステルの加水分解を介して作用する Wnt シグナル伝達の負の調節因子です。カルボキシルエステラーゼ-IN-3 は、がん疾患の研究の可能性を秘めています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2764748-92-5
Sample solution is provided at 25 µL, 10mM.
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Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease[1].
[1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.
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