BTSA1 |
| カタログ番号GC39355 |
BTSA1 は、250 nM の IC50 と 144 nM の EC50 を持つ強力で高親和性の経口活性 BAX アクチベーターです。 BTSA1 は N 末端の活性化部位に高い親和性と特異性で結合し、BAX を介したアポトーシスにつながる BAX の構造変化を誘導します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 314761-14-3
Sample solution is provided at 25 µL, 10mM.
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BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].
[1]. Reyna DE, et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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