Cearoin |
| カタログ番号GC61865 |
Cearoin は、ROS の産生と ERK の活性化を通じて、オートファジーとアポトーシスを増加させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 52811-37-7
Sample solution is provided at 25 µL, 10mM.
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Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].
Cearoin (10-80 µM) induces cell death in a dose-dependent manner[1]. Cearoin (10-80 µM) increases the phosporylation of ERK in SH-SY5Y cells[1]. Cearoin (5-80 µM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1].
References:
[1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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