Chamazulene (Synonyms: Dimethulene) |
| カタログ番号GC52081 |
天然化合物であるチャマズレンは、ロイコトリエン B4 形成の抗酸化型阻害剤です 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 529-05-5
Sample solution is provided at 25 µL, 10mM.
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Chamazulene is a terpene that has been found in chamomile (M. recutita) flowers and has anti-inflammatory and antioxidant activities.1 It reduces increases in matrix metalloproteinase-3 (MMP-3), MMP-9, COX-2, inducible nitric oxide synthase (iNOS), and p65 NF-κB levels in IL-1β-stimulated primary rat chondrocytes when used at a concentration of 10 µg/ml. Chamazulene (10 and 20 µg/ml) reduces IL-1β-induced production of malondialdehyde (MDA) and increases levels of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) in primary rat chondrocytes. In vivo, chamazulene (25 and 50 mg/kg) reduces hind paw volume, serum levels of MDA, TNF-α, and IL-6, and cartilage erosion in a rat model of osteoarthritis induced by complete Freund’s adjuvant (CFA).
1.Ma, D., He, J., and He, D.Chamazulene reverses osteoarthritic inflammation through regulation of matrix metalloproteinases (MMPs) and NF-kβ pathway in in-vitro and in-vivo modelsBiosci. Biotechol. Biochem.84(2)402-410(2020)
| Cas No. | 529-05-5 | SDF | |
| 同義語 | Dimethulene | ||
| Canonical SMILES | CCC1=CC=C(C)C2=CC=C(C)C2=C1 | ||
| Formula | C14H16 | M.Wt | 184.3 |
| 溶解度 | Ethanol: soluble,Water: very slightly soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.4259 mL | 27.1297 mL | 54.2594 mL |
| 5 mM | 1.0852 mL | 5.4259 mL | 10.8519 mL |
| 10 mM | 0.5426 mL | 2.713 mL | 5.4259 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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