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Chroman 1 dihydrochloride

カタログ番号GC71281

Chroman 1 dihydrochlorideは、強力で選択的なロック阻害剤です。

Products are for research use only. Not for human use. We do not sell to patients.

Chroman 1 dihydrochloride 化学構造

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$232.00
在庫あり
5 mg
$207.00
在庫あり
10 mg
$331.00
在庫あり
25 mg
$599.00
在庫あり
50 mg
$851.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com


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Sample solution is provided at 25 µL, 10mM.

Description of Chroman 1 dihydrochloride

Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor. Chroman 1 dihydrochloride is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM).Chroman 1 dihydrochloride also has inhibitory activity against MRCK, with an IC50 of 150 nM.

Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells[1].

Chemical Properties of Chroman 1 dihydrochloride

Cas No. SDF
Formula C24H30Cl2N4O4 M.Wt 509.43
溶解度 H2O : 100 mg/mL (196.30 mM; Need ultrasonic); DMSO : 100 mg/mL (196.30 mM; Need ultrasonicHygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Storage 4°C, sealed storage, away from moisture
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Chroman 1 dihydrochloride

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.963 mL 9.8149 mL 19.6298 mL
5 mM 0.3926 mL 1.963 mL 3.926 mL
10 mM 0.1963 mL 0.9815 mL 1.963 mL
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**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

In vivo Formulation Calculator (Clear solution) of Chroman 1 dihydrochloride

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for Chroman 1 dihydrochloride

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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