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Chroman 1 (hydrochloride hydrate) (Synonyms: (S)-Chroman 1)

カタログ番号GC49334

ROCK2阻害剤

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Chroman 1 (hydrochloride hydrate) 化学構造

Cas No.: N/A

サイズ 価格 在庫数 個数
1 mg
$77.00
在庫あり
5 mg
$328.00
在庫あり
10 mg
$540.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

クロマン1は、Rho関連キナーゼ2(ROCK2; IC50= <1 nM)の阻害剤です。1 PKAおよびCdc42結合キナーゼ(MRCKα; IC50s = 1,740および127 nM、それぞれ)に対してROCK2を選択的に阻害します。 クロマン1は、細胞ベースのアッセイでミオシン軽鎖(MLC)のリン酸化を阻害します(IC50= <4 nM)。

1. Chen, Y.T., Vojkovsky, T., Fang, X., et al. 強力なクロマンベースのRhoキナーゼ(ROCK-II)阻害剤の不斉合成。Med. Chem. Commun. 2(1)73-75 (2011)

Chemical Properties

Cas No. N/A SDF
同義語 (S)-Chroman 1
Canonical SMILES CN(C)CCOC(C=C(C1=CNN=C1)C=C2)=C2NC([C@H]3CC4=CC(OC)=CC=C4OC3)=O.Cl.Cl.O
Formula C24H28N4O4·2HCl [XH2O] M.Wt 527.4
溶解度 DMSO: ≥ 40 mg/mL Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.8961 mL 9.4805 mL 18.9609 mL
5 mM 0.3792 mL 1.8961 mL 3.7922 mL
10 mM 0.1896 mL 0.948 mL 1.8961 mL
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**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

Review for Chroman 1 (hydrochloride hydrate)

Average Rating: 5 ★★★★★ (Based on Reviews and 16 reference(s) in Google Scholar.)

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