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Cl-Necrostatin-1 (Synonyms: 7-Cl-Nec-1, 7-Cl-Necrostatin-1, Nec-1f)

カタログ番号GC49556

RIPK1阻害剤

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Cl-Necrostatin-1 化学構造

Cas No.: 862377-51-3

サイズ 価格 在庫数 個数
1 mg
$68.00
在庫あり
5 mg
$318.00
在庫あり
10 mg
$603.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Cl-Necrostatin-1は、受容体相互作用性プロテインキナーゼ1(RIPK1)の阻害剤です。1 0.3、3、および30μMの濃度で使用される場合にRIPK1活性を抑制します。また、Fas関連死因子タンパク質(FADD)が欠乏したJurkat細胞においてTNF-α誘発性壊死を抑制します(EC50=180 nM)。これはデスドメイン受容体シグナル伝達に対するカスパーゼ活性化を防止する修飾です。2,3 Cl-Necrostatin-1(4mM溶液の2μl、i.c.v.)は、中大脳動脈閉塞(MCAO)マウスモデルにおいて前後閉塞時または後閉塞時の投与で梗塞範囲を減少させます。

1. Degterev、Hitomi、Germscheidなど。Necrostatinsの特定の細胞標的としてRIP1キナーゼを同定。Nat。Chem.Biol.4(5)313-321(2008) 2. Teng、Degterev、Jagtapなど。新しいネクロプトーシス阻害剤の構造活性関係研究Bioorg。Med.Chem.Lett.15(22)5039-5044(2005) 3. Degterev、Huang、Boyceなど。虚血性脳障害に対する治療的可能性を持つ非アポトーシス細胞死の化学的阻害剤Nat。Chem.Biol.1(2)112-119(2005)

Chemical Properties

Cas No. 862377-51-3 SDF Download SDF
同義語 7-Cl-Nec-1, 7-Cl-Necrostatin-1, Nec-1f
Canonical SMILES O=C(C(N1)CC2=CNC3=C(Cl)C=CC=C32)N(C)C1=S
Formula C13H12ClN3OS M.Wt 293.8
溶解度 DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 14 mg/ml,Ethanol: 3 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.4037 mL 17.0184 mL 34.0368 mL
5 mM 0.6807 mL 3.4037 mL 6.8074 mL
10 mM 0.3404 mL 1.7018 mL 3.4037 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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