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Corticotropin-releasing factor ovine (Ovine CRF)

カタログ番号GC32940

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Corticotropin-releasing factor ovine (Ovine CRF) 化学構造

Cas No.: 79804-71-0

サイズ 価格 在庫数 個数
500μg
$110.00
在庫あり
1mg
$175.00
在庫あり
5mg
$597.00
在庫あり
10mg
$1,011.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of Corticotropin-releasing factor ovine (Ovine CRF)

Corticotropin-releasing factor (ovine) is a preferential CRF1 receptor agonist.

Corticotropin-releasing factor (ovine), a preferential CRF1 receptor agonist, shows almost 200-fold greater affinity for the CRF1 than CRF2 receptor[1].

Corticotropin-releasing factor (ovine) (Ovine CRF: 0.1-2.5 nM) stimulates corticotropin release by pituitaries of Wistar rats and this effect is augmented two- to three fold in the presence of arginine vasopressin (0.09-0.9 mIU/ml) or oxytocin (0.9-90 mIU/ml) [2]. oCRF (10 μg) suppresses 6-h intake of cafeteria diet-fed rats without regard to macronutrient composition. Rather, oCRF most potently suppresses intake of preferred food items[1].

[1]. Eric P. Zorrilla et al. Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)2 Agonist, and Ovine CRF, a CRF1 Agonist, Differentially Alter Feeding and Motor Activity. Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1027-1034; [2]. Antoni FA et al. Oxytocin as well as vasopressin potentiate ovine CRF in vitro. Peptides. 1983 Jul-Aug;4(4):411-5.

Chemical Properties of Corticotropin-releasing factor ovine (Ovine CRF)

Cas No. 79804-71-0 SDF
Canonical SMILES Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2
Formula C205H339N59O63S M.Wt 4670.31
溶解度 Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Corticotropin-releasing factor ovine (Ovine CRF)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 0.2141 mL 1.0706 mL 2.1412 mL
5 mM 0.0428 mL 0.2141 mL 0.4282 mL
10 mM 0.0214 mL 0.1071 mL 0.2141 mL
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In vivo Formulation Calculator (Clear solution) of Corticotropin-releasing factor ovine (Ovine CRF)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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