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CRF, bovine TFA (Synonyms: Corticotropin Releasing Factor bovine TFA)

カタログ番号GC34542

CRF、ウシ (TFA) は CRF 受容体の強力なアゴニストであり、[125I-Tyr]ヒツジ CRF を 3.52 nM の Ki で置換します 。

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CRF, bovine TFA 化学構造

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500μg
$200.00
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1mg
$322.00
在庫あり
5mg
$1,101.00
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Sample solution is provided at 25 µL, 10mM.

Description of CRF, bovine TFA

CRF, bovine (TFA) is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. Ki: 3.52 nM (CRF receptor)[1].

CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. CRF shows pEC50s of 11.16, 8.53 and 8.70 for human CRF1, human CRF2 and rat CRF2α[2]. CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and leads to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects. CRF affects brain microvessel endothelial cells (BMEC) structure or function, CRF (100 nM) significantly increases cAMP in BMEC[3].

[1]. CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. CRF shows pEC50s of 11.16, 8.53 and 8.70 for human CRF1, human CRF2 and rat CRF2α[2]. CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and leads to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects. CRF affects brain microvessel endothelial cells (BMEC) structure or function, CRF (100 nM) significantly increases cAMP in BMEC[3]. [2]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. [3]. Esposito P, et al. Corticotropin-releasing factor (CRF) can directly affect brain microvessel endothelial cells. Brain Res. 2003 Apr 11;968(2):192-8.

Chemical Properties of CRF, bovine TFA

Cas No. SDF
同義語 Corticotropin Releasing Factor bovine TFA
Formula C208H341F3N60O65S M.Wt 4811.36
溶解度 DMSO : 50 mg/mL (Need ultrasonic); H2O : 25 mg/mL (Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CRF, bovine TFA

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1 mg 5 mg 10 mg
1 mM 0.2078 mL 1.0392 mL 2.0784 mL
5 mM 0.0416 mL 0.2078 mL 0.4157 mL
10 mM 0.0208 mL 0.1039 mL 0.2078 mL
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