Cysteamine-d4 (hydrochloride) (Synonyms: β-Mercaptoethylamine-d4) |
| カタログ番号GC48965 |
システアミン定量のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1219805-04-5
Sample solution is provided at 25 µL, 10mM.
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Cysteamine-d4 is intended for use as an internal standard for the quantification of cysteamine (hydrochloride) by GC- or LC-MS. Cysteamine is a stable aminothiol with radioprotective activities.1 It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner.1,2 Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects.2 In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts.3 Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
1.Nelson, A.The protective effect of cysteamine on young mice exposed to roentgen raysActa. Radiol.42(6)485-493(1954) 2.Devik, F., and Lothe, F.The effect of cysteamine, cystamine and hypoxia on mortality and bone marrow chromosome aberrations in mice after total body roentgen irradiationActa. Radiol.44(3)243-248(1955) 3.Thoene, J.G., Oshima, R.G., Crawhall, J.C., et al.Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivoJ. Clin. Invest.58(1)180-189(1976)
| Cas No. | 1219805-04-5 | SDF | |
| 同義語 | β-Mercaptoethylamine-d4 | ||
| Canonical SMILES | NC([2H])([2H])C([2H])([2H])S.Cl | ||
| Formula | C2H3D4NS•HCl | M.Wt | 117.6 |
| 溶解度 | DMSO: slightly soluble,Methanol: slightly soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 8.5034 mL | 42.517 mL | 85.034 mL |
| 5 mM | 1.7007 mL | 8.5034 mL | 17.0068 mL |
| 10 mM | 0.8503 mL | 4.2517 mL | 8.5034 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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