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Diapocynin

カタログ番号GC18517

ジアポシニンは、抗炎症作用と抗酸化作用を持つNADPHオキシダーゼ阻害剤アポシニンの二量体形態です。

Products are for research use only. Not for human use. We do not sell to patients.

Diapocynin 化学構造

Cas No.: 29799-22-2

サイズ 価格 在庫数 個数
1mg
$44.00
在庫あり
5mg
$110.00
在庫あり
10mg
$195.00
在庫あり
25mg
$427.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of Diapocynin

Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin that has anti-inflammatory and antioxidant activities. Diapocynin inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in peripheral blood mononuclear cells (PMBCs). It inhibits production of reactive oxygen species (ROS), calcium-independent isoform of phospholipase A2 (iPLA2) function, and reduces Ca2+ influx through store-operated and stretch-activated channels (SOCs and SACs, respectively) in dystrophic myotubes; all functions in the pathogenic cascade leading to muscular dystrophy. Diapocynin also reverses motor coordination deficits in the LRRK2R1441G mouse model of early Parkinson's disease.

Chemical Properties of Diapocynin

Cas No. 29799-22-2 SDF
Chemical Name 1,1'-(6,6'-dihydroxy-5,5'-dimethoxy[1,1'-biphenyl]-3,3'-diyl)bis-ethanone
Canonical SMILES OC1=C(C2=C(O)C(OC)=CC(C(C)=O)=C2)C=C(C(C)=O)C=C1OC
Formula C18H18O6 M.Wt 330.3
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 20 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Diapocynin

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1 mg 5 mg 10 mg
1 mM 3.0276 mL 15.1378 mL 30.2755 mL
5 mM 0.6055 mL 3.0276 mL 6.0551 mL
10 mM 0.3028 mL 1.5138 mL 3.0276 mL
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In vivo Formulation Calculator (Clear solution) of Diapocynin

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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