(±)-Dunnione (Synonyms: NSC 95403) |
カタログ番号GC18787 |
(±)-ダニオンは、多様な生物学的活性を持つ天然のナフトキノンです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 521-49-3
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(±)-ダニオンは、多様な生物学的活性を持つ天然のナフトキノンです。[1][2][3][4] それは、体外(MICs = 5-20 mg/L)および感染した小麦や大麦の植物(EC50s = 2-20 mg/L)において、10種類の農業上重要な植物菌に対して殺菌活性を示します[1]。 (±)-ダニオンはまた、T. cruziエピマスチゴートの成長を抑制します(IC50 = 4.01 μM)[2]。NAD(P)H:キノンオキシドレダクターゼ1(NQO1)の基質であり、反応性酸素種(ROS)の生成を増加させてA549肺癌細胞の細胞死を誘導します(IC50=6.1μM).[3](±)-ダニオン(20mg/kg/日×4日間投与)はマウスにおいてcisplatinによって引き起こされる炎症性サイトカイン産生と小腸障害を防止し、細胞内NAD+ を増加させます.[4]
参考文献:
[1]. Khambay, B.P.S.、Batty, D.、Jewess, P.J.、他。Dunnioneとそのアナログの作用機序および殺虫活性 Pest. Manag. Sci. 59(2), 174-182 (2003)。
[2]. Salas, C.O.、Faúndez, M.、Morello, A.、他。Trypanosoma cruziに対して有効な天然および合成ナフトキノン:Chagas病の新薬開発への初期段階 Curr.Med.Chem。18(1), 144-161(2011)
[3] . Bian,J。,Xu,L。,Deng,B。,他。NAD(P)H:quinone oxidoreductase 1(NQO1)の基質としての(±)-dunnioneおよびそのortho-quinoneアナログの合成と評価 Bioorg.Med.Chem.Lett。25(6),1244-1248 (2015)。
[4] 。Pandit,A。,Kim,H.-J。,Oh,G.-S。,他。DunnioneはNAD(+)代謝を調節することによりcisplatin誘導性小腸障害を改善する Biochem.Bioph.Res.Commun。467(4),697-703 (2015)。
Cas No. | 521-49-3 | SDF | |
同義語 | NSC 95403 | ||
Chemical Name | 2,3-dihydro-2,3,3-trimethyl-naphtho[1,2-b]furan-4,5-dione | ||
Canonical SMILES | O=C(C1=CC=CC=C1C2=C3C(C)(C)C(C)O2)C3=O | ||
Formula | C15H14O3 | M.Wt | 242.3 |
溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 4.1271 mL | 20.6356 mL | 41.2712 mL |
5 mM | 0.8254 mL | 4.1271 mL | 8.2542 mL |
10 mM | 0.4127 mL | 2.0636 mL | 4.1271 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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