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(E/Z)-GO289

カタログ番号GC62735

(E/Z)-GO289 は、強力で選択的なカゼインキナーゼ 2 (CK2) 阻害剤です (IC50=7 nM)。 (E/Z)-GO289 は概日周期を大幅に延長します。 (E/Z)-GO289 は、細胞時計機能と相関する癌細胞増殖の細胞型依存性阻害を示します。

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(E/Z)-GO289 化学構造

Cas No.: 694522-87-7

サイズ 価格 在庫数 個数
5 mg
$85.00
在庫あり
10 mg
$140.00
在庫あり
25 mg
$275.00
在庫あり
50 mg
$441.00
在庫あり
100 mg
$711.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function[1].

(E/Z)-GO289 is a potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.(E/Z)-GO289 shows an IC50 of 13 μM for PIM2 and is >1000 times higher than that for CK2[1].(E/Z)-GO289 (3-9 μM; 2 days) strongly inhibits Caki-2, A498, and 769-P cells[1]. (E/Z)-GO289 enables manipulation of clock protein phosphorylation and cancer cell growth[1].

[1]. Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5(1):eaau9060. Published 2019 Jan 23.

Chemical Properties

Cas No. 694522-87-7 SDF
Formula C17H15BrN4O2S M.Wt 419.3
溶解度 Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3849 mL 11.9246 mL 23.8493 mL
5 mM 0.477 mL 2.3849 mL 4.7699 mL
10 mM 0.2385 mL 1.1925 mL 2.3849 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)

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