(E/Z)-Sivopixant (Synonyms: (E/Z)-S-600918) |
| カタログ番号GC62560 |
(E/Z)-Sivopixant ((E/Z)-S-600918) は、4 nM の IC50 を持つ強力な P2X3 受容体アンタゴニストです。
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Cas No.: 1640808-39-4
Sample solution is provided at 25 µL, 10mM.
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(E/Z)-Sivopixant (Compound I-127) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research[1].
ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors It has been suggested that it is involved in information transmission in the respiratory organs[1].
[1]. Kai, Hiroyuki, et al. Amino-triazine derivatives and pharmaceutical composition containing said derivatives. WO2014200078A1.
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