Enterostatin (human, mouse, rat) (trifluoroacetate salt) (Synonyms: APGPR) |
| カタログ番号GC49324 |
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Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Enterostatin is an endogenous pentapeptide fragment involved in the regulation of food intake.1 It is released from its precursor protein, procolipase, during digestion and acts in the peripheral and central nervous systems to reduce food, especially fat, intake through the vagus nerve in the periphery and κ-opioid-, serotonin (5-HT) receptor subtype 5-HT1B-, and cholecystokinin-mediated signaling pathways in the brain.1,2 Enterostatin binds to mitochondrial complex V, also known as F1F0 ATP synthase, in a cell-free assay and inhibits ATP production and increases thermogenesis in INS-1 insulinoma cells.3 It reduces body weight in rats fed a high-fat diet but not mice fed a chow diet. Enterostatin (1 nmol, i.c.v) reduces food intake in wild-type, but not melanocortin receptor 4 knockout (Mc4r-/-), mice.4 It also enhances memory consolidation in mice in a passive avoidance test when administered at a dose of 300 mg/kg, an effect that can be blocked by the cholecystokinin 1 (CCK1) receptor antagonist lorglumide .5
1.York, D.A., and Park, M.Enterostatin, a peptide regulator of dietary fat ingestionHandbook of biologically active peptides969-974(2006) 2.Lin, L., and York, D.A.5-HT1B receptors modulate the feeding inhibitory effects of enterostatinBrain Res.1062(1-2)26-31(2005) 3.Berger, K., Sivars, U., Winzell, M.S., et al.Mitochondrial ATP synthase—a possible target protein in the regulation of energy metabolism in vitro and in vivoNurtr. Neurosci.5(3)201-210(2002) 4.Lin, L., Park, M., and York, D.A.Enterostatin inhibition of dietary fat intake is modulated through the melanocortin systemPeptides28(3)643-649(2007) 5.Ohinata, K., Sonoda, S., Shimano, T., et al.Enterostatin (APGPR) enhances memory consolidation in micePeptides28(3)719-721(2007)
| Cas No. | N/A | SDF | |
| 同義語 | APGPR | ||
| Canonical SMILES | N=C(N)NCCC[C@@H](C(O)=O)NC([C@H]1N(C(CNC([C@H]2N(C([C@H](C)N)=O)CCC2)=O)=O)CCC1)=O.OC(C(F)(F)F)=O | ||
| Formula | C21H36N8O6·XCF3COOH | M.Wt | 496.6 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0137 mL | 10.0685 mL | 20.1369 mL |
| 5 mM | 0.4027 mL | 2.0137 mL | 4.0274 mL |
| 10 mM | 0.2014 mL | 1.0068 mL | 2.0137 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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