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FIDAS-3

カタログ番号GC62214

FIDAS-3 はスチルベン誘導体であり、メチオニン S-アデノシルトランスフェラーゼ 2A (MAT2A) に対する IC50 が 4.9 μM の強力な Wnt 阻害剤です。 FIDAS-3 は、MAT2A 結合に関して S-アデノシルメチオニン (SAM) と効果的に競合します。 FIDAS-3 には抗がん作用があります。

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FIDAS-3 化学構造

Cas No.: 1266684-01-8

サイズ 価格 在庫数 個数
5 mg
$117.00
在庫あり
10 mg
$216.00
在庫あり
25 mg
$414.00
在庫あり
50 mg
$675.00
在庫あり
100 mg
$1,071.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells[1]. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1[1]. FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells[1].

FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors[2].

[1]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803.
[2]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54(5):1288-97.

Chemical Properties

Cas No. 1266684-01-8 SDF
Formula C16H15F2N M.Wt 259.29
溶解度 DMSO : 100 mg/mL (385.67 mM; Need ultrasonic) Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.8567 mL 19.2834 mL 38.5669 mL
5 mM 0.7713 mL 3.8567 mL 7.7134 mL
10 mM 0.3857 mL 1.9283 mL 3.8567 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 8 reference(s) in Google Scholar.)

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