(Des-Glu²²)-Amyloid β-Protein (1-40) |
カタログ番号GA20095 |
大阪変異体は、APPとAβにおいて最初の欠失型変異である。Aβ E22delta ミュータントは、2つの主要なAβ-分解酵素であるネプリシンとインスリン分解酵素による分解に対してより耐性があります。合成ミュータント Aβ は、強化されたオリゴマー化を示すがフィブリル化はしない異常な凝集特性を示しました。また、野生型 Aβ よりも海馬長期増強を効率的に抑制します。E693delta 変異を含む APP を持つトランスジェニックマウスモデルが開発されました。APP(OSK)-Tg マウスでは、8か月の時点で細胞内 Aβ E22delta オリゴマーと記憶障害が観察されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1678416-36-8
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
大阪変異は、APPとAβで同定された最初の欠失型変異です。 Aβ E22delta ミュータントは、2つの主要なAβ分解酵素であるネプリシンとインスリン分解酵素による分解に対してより耐性があります。合成ミュータントAです。
Cas No. | 1678416-36-8 | SDF | |
Formula | C189H288N52O55S | M.Wt | 4200.75 |
溶解度 | Soluble in DMSO | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 0.2381 mL | 1.1903 mL | 2.3805 mL |
5 mM | 0.0476 mL | 0.2381 mL | 0.4761 mL |
10 mM | 0.0238 mL | 0.119 mL | 0.2381 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
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