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(Des-Glu²²)-Amyloid β-Protein (1-40)

カタログ番号GA20095

大阪変異体は、APPとAβにおいて最初の欠失型変異である。Aβ E22delta ミュータントは、2つの主要なAβ-分解酵素であるネプリシンとインスリン分解酵素による分解に対してより耐性があります。合成ミュータント Aβ は、強化されたオリゴマー化を示すがフィブリル化はしない異常な凝集特性を示しました。また、野生型 Aβ よりも海馬長期増強を効率的に抑制します。E693delta 変異を含む APP を持つトランスジェニックマウスモデルが開発されました。APP(OSK)-Tg マウスでは、8か月の時点で細胞内 Aβ E22delta オリゴマーと記憶障害が観察されます。

Products are for research use only. Not for human use. We do not sell to patients.

(Des-Glu²²)-Amyloid β-Protein (1-40) 化学構造

Cas No.: 1678416-36-8

サイズ 価格 在庫数 個数
0.5mg
$285.00
在庫あり
1mg
$486.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

大阪変異は、APPとAβで同定された最初の欠失型変異です。 Aβ E22delta ミュータントは、2つの主要なAβ分解酵素であるネプリシンとインスリン分解酵素による分解に対してより耐性があります。合成ミュータントAです。

Chemical Properties

Cas No. 1678416-36-8 SDF
Formula C189H288N52O55S M.Wt 4200.75
溶解度 Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.2381 mL 1.1903 mL 2.3805 mL
5 mM 0.0476 mL 0.2381 mL 0.4761 mL
10 mM 0.0238 mL 0.119 mL 0.2381 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 40 reference(s) in Google Scholar.)

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