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Ganglioside GM1 Asialo Mixture (Synonyms: ASGM1, Asialo GM1, Gangliotetraosylceramide)

カタログ番号GC43730

ガングリオシドGM1アシアロは細胞脂質ラフトの成分であり、ニューラミニダーゼによるガングリオシドGM1から唾液酸残基を切断することで形成されます。

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Ganglioside GM1 Asialo Mixture 化学構造

Cas No.: 71012-19-6

サイズ 価格 在庫数 個数
500μg
$351.00
在庫あり
1mg
$668.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

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Background

ガングリオシドGM1アシアロは、細胞脂質ラフトの成分であり、ニューラミニダーゼによるガングリオシドGM1から唾液酸残基を切断することで形成されます。ガングリオシドGM1アシアロは、P. aeruginosaフラジェリンの糖蛋白受容体であり、抗ガングリオシドGM1アシアロ抗体やフラジェリンに刺激された場合には細胞外ATP放出、カルシウム動員およびERK1/2のリン酸化など宿主細胞内防御反応を促進します。自然キラー(NK)細胞およびCD8+ T細胞中のガングリオシドGM1アシアロ陽性割合は、呼吸器合胞体ウイルス(RSV)感染マウスモデルでは健康な動物と比較して増加します。ガングリオシドGM1アシアロ陽性NKおよびT細胞の減少は肺IFN-γレベル低下、体重減少およびRSV感染マウスにおける肺ウイルス量の増加につながります。ガングリオシドGM1アシアロ混合物には、C18:1およびC20:1スフィンゴイドバックボーンを持つガングリオシドGM1アシアロ分子種が含まれています。

Chemical Properties

Cas No. 71012-19-6 SDF
同義語 ASGM1, Asialo GM1, Gangliotetraosylceramide
Canonical SMILES [H][C@](CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)O)CO)O)O)CO)([C@](O)(/C=C/CCCCCCCCCCCCC)[H])NC(CCCCCCCCCCCCCCCCC)=O
Formula C62H114N2O23 (for Sphingosine C18:1) M.Wt 1255.6
溶解度 Chloroform:Methanol (2:1): Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.7964 mL 3.9822 mL 7.9643 mL
5 mM 0.1593 mL 0.7964 mL 1.5929 mL
10 mM 0.0796 mL 0.3982 mL 0.7964 mL
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