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(+)-Borneol (Synonyms: D-Borneol, (1R)-(+)-Borneol, (+)-endo-Borneol)

カタログ番号GC34954

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(+)-Borneol 化学構造

Cas No.: 464-43-7

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10mM (in 1mL DMSO)
$52.00
在庫あり
100mg
$46.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. EC50: 248 μM (GABA receptor)[1]

(+)-Borneol is present in the essential oils of numerous medicinal plants, including valerian (Valeriana officinalis), chamomile (Matricaria chamomilla) and lavender (Lavandula officinalis). Extracts of these plants are used traditionally to relieve anxiety, restlessness and insomnia. (+)-Borneol is found to have a highly efficacious positive modulating action at GABAA receptors. (+)-Borneol enhances the action of low concentrations of GABA by more than 1000% (EC50=248 μM)[1].

(+)-Borneol has remarkable anti-hyperalgesic effects on neuropathic and inflammatory pain in animal models. Both oral administration (125, 250 or 500 mg/kg) and intrathecal injection (i.t.) (15, 30 and 60 μg) of (+)-Borneol reduce mechanical hypersensitivity dose-dependently in SNL and CFA models. The antihyperalgesic effects of (+)-Borneol are abolished by a selective GABAA receptor (GABAAR) antagonist bicuculline. (+)-Borneol (500 mg/kg, p.o. or 60 μg, i.t.) does not influence motor function[2]. After per oral application, (+)-Borneol is absorbed rapidly into the brain and could be determined 5 min after dosing. The maximal brain concentration (86.52 μg/g) is reached after 1 h post-dosing. (+)-Borneol could affect the contents of AA neurotransmitters in mice brain and the change in excitatory ratio leads to borneol's double side effects on the central nervous system[3].

[1]. Granger RE, et al. (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinantalpha1beta2gamma2L GABA(A) receptors. Biochem Pharmacol. 2005 Apr 1;69(7):1101-11. [2]. Jiang J, et al. (+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. Eur J Pharmacol. 2015 Jun 15;757:53-8.

Chemical Properties

Cas No. 464-43-7 SDF
同義語 D-Borneol, (1R)-(+)-Borneol, (+)-endo-Borneol
Canonical SMILES O[C@@H]1[C@](C2(C)C)(C)CC[C@]2([H])C1
Formula C10H18O M.Wt 154.25
溶解度 DMSO: ≥ 100 mg/mL (648.30 mM); Water: < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 6.483 mL 32.4149 mL 64.8298 mL
5 mM 1.2966 mL 6.483 mL 12.966 mL
10 mM 0.6483 mL 3.2415 mL 6.483 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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