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(20S)-Protopanaxatriol (Synonyms: 20(S)-APPT, 20(S)-PPT)

カタログ番号GC34965

活性ジンセノサイド代謝物

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(20S)-Protopanaxatriol 化学構造

Cas No.: 34080-08-5

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$44.00
在庫あり
5mg
$40.00
在庫あり
10mg
$58.00
在庫あり
50mg
$160.00
在庫あり
100mg
$259.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(20S)-プロトパナキサトリオールは、ジンセノシドの代謝物であり、グルココルチコイド受容体(GR)およびエストロゲン受容体(ER)を介して作用し、またLXRα阻害剤でもあります。 グルココルチコイド受容体、エストロゲン受容体[1]、LXRα[2]

(20S)-プロトパナキサトリオールは、ヒト臍帯静脈内皮細胞(HUVECs)においてグルココルチコイド受容体(GR)とエストロゲン受容体(ER)を介して作用します。 (20S)-プロトパナキサトリオール(g-PPT)は、HUVECsにおいてEC50が482 nMで[Ca2+]iを増加させます。 (20S)-プロトパナキサトリオール(1μM)はERβを介してNO産生を上昇させます。 (20S)-プロトパナキサトリオール(PPT)はGal4-LXRα LBDの自律的な転写活性化、T0901317依存性のSREBP-1c及びそのプロモーターの転写も阻害します。(20S)-プロトパナキサ ート リ オ ー ル (10μg / mL)は、RNAポリメラーゼIIが SREBP-1c のLXRE領域に結合することを阻止しました。また、(20S) - プロタパナ キ サ ート リ オ ー ル は、脂肪生成に関連するLXRα標的遺伝子のT0901317依存性の転写も抑制し、原発性肝細胞におけるT0901317誘導性の細胞内トリグリセリド(TG)蓄積を減少させますが、LXRα標的遺伝子であるABCA1の転写は変化しません[2]。

References:
[1]. Leung KW, et al. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb;156(4):626-37.
[2]. Oh GS, et al. 20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes. J Pharmacol Sci. 2015 Jun;128(2):71-7.

Chemical Properties

Cas No. 34080-08-5 SDF
同義語 20(S)-APPT, 20(S)-PPT
Canonical SMILES C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(C[C@H](O)[C@@]2([H])C3(C)C)[C@]4([C@@]1([H])[C@]([C@@](C)(O)CC/C=C(C)/C)([H])CC4)C
Formula C30H52O4 M.Wt 476.73
溶解度 DMSO: 100 mg/mL (209.76 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0976 mL 10.4881 mL 20.9762 mL
5 mM 0.4195 mL 2.0976 mL 4.1952 mL
10 mM 0.2098 mL 1.0488 mL 2.0976 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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