ALK-IN-6 |
| カタログ番号GC35290 |
ALK-IN-6 (化合物 11) は、生物学的に利用可能な未分化リンパ腫キナーゼ (ALK) の経口阻害剤であり、IC50 値は、ALK 野生型、ALK F1196M および ALK F1174L についてそれぞれ 71 nM、18.72 nM および 36.81 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055821-33-3
Sample solution is provided at 25 µL, 10mM.
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ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively[1]. IC50: 71 nM (ALK wild), 18.72 nM (ALK F1196M), 36.81 nM (ALK F1174L)[1].
[1]. Das D, et al. Design, synthesis of orally bioavailable novel anaplastic lymphoma kinase (ALK) inhibitor diphenylaminopyrimidine analogs and efficacy study on NCI-H2228 xenografts mice model. Bioorg Med Chem Lett. 2019 Jun 15;29(12):1514-1517.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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