Balsalazide sodium hydrate |
| カタログ番号GC35466 |
バルサラジド ナトリウム水和物は、IL-6/STAT3 経路の調節を介して大腸炎関連の発がんを抑制する可能性があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 150399-21-6
Sample solution is provided at 25 µL, 10mM.
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Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. STAT3 IL-6
At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].
[1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61. [2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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