DK419 |
カタログ番号GC35873 |
DK419 は、0.19 μM の IC50 を持つ強力な経口活性 Wnt/β-カテニン シグナル伝達阻害剤です。 DK419 は、Axin2、β-カテニン、c-Myc、Cyclin D1、および Survivin のタンパク質レベルを低下させ、pAMPK の産生を誘導します。
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Cas No.: 2102672-22-8
Sample solution is provided at 25 µL, 10mM.
DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1]. Wnt/β-catenin[1]
[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.
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