Fibronectin Adhesion-promoting Peptide (Synonyms: Heparin Binding Peptide) |
カタログ番号GC36041 |
フィブロネクチン接着促進ペプチドは、線維芽細胞においてストレスファイバーや焦点接着を強力に誘導し、動脈硬化性心血管疾患などの関連する血栓形成に関与しています。
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Cas No.: 125720-21-0
Sample solution is provided at 25 µL, 10mM.
Fibronectin Adhesion-promoting Peptide (Trp-Glu-Pro-Pro-Arg-Ala-Arg-Ile) has medicinal interest as well as well-characterized structure. From a medical application point of view, this sequence (WQPPRARI) was found in the carboxy-terminated heparin-binding domain of fibronectin repeats III14. It is a potent inducer of stress fibers and focal adhesion in fibroblasts, which are involved in forming thrombosis related to diseases such as atherosclerotic cardiovascular disease.[2]
Fibronectin Adhesion-promoting Peptide has a low molecular weight of 1114.25 g/mol and lacks a secondary structure from a structural point of view. As such, irreversible adsorption based on surface-induced conformational changes is expected to be unimportant. Yet, this peptide provides a large enough structure for analysis by the BIAcore X SPR instrument, which has a detection limit of ∼200 Da. Therefore, SPR was used to measure the adsorption properties of Fibronectin Adhesion-promoting Peptide on the polymer surface. SPR sensorgram of Fibronectin Adhesion-promoting Peptide adsorption on confined poly(2-vinylpyridine) surface were run at different concentrations of peptide (in mg/mL) in pH 7 HEPES buffer: 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.8, 1.0, and 1.5, at T = 25 °C. The flow rate was 40 μL/min.[2]
Moreover, Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of RCE cells in a concentration-dependent manner. [1]
References:
[1]. Mooradian, D L et al. Characterization of FN-C/H-V, a novel synthetic peptide from fibronectin that promotes rabbit corneal epithelial cell adhesion, spreading, and motility. Investigative ophthalmology & visual science vol. 34,1 (1993): 153-64.
[2]. Li, Xiao et al. Thermodynamic studies on the adsorption of Fibronectin Adhesion-promoting Peptide on nanothin films of poly(2-vinylpyridine) by SPR. Biomacromolecules vol. 5,3 (2004): 869-76.
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