2-Methoxycinnamaldehyde |
| カタログ番号GC38318 |
2-メトキシシンナムアルデヒド (o-メトキシシンナムアルデヒド) は、抗腫瘍活性を持つシンナモム カシアの天然化合物です。 2-メトキシシンナムアルデヒドは増殖を阻害し、ミトコンドリア膜電位 (δψm) の損失、カスパーゼ-3 とカスパーゼ-9 の両方の活性化によってアポトーシスを誘導します。 2-メトキシシンナムアルデヒドは、血小板由来成長因子 (PDGF) による HASMC の移動を効果的に阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1504-74-1
Sample solution is provided at 25 µL, 10mM.
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2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity[1][2][3]. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (δψm) loss, activation of both caspase-3 and caspase-9[2]. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration[3].
[1]. Wong HY, et al. Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytother Res. 2016 Feb;30(2):331-40. [2]. Liu YH, et al. Cinnamomum verum ingredient 2-methoxycinnamaldehyde: a new antiproliferative drug targeting topoisomerase I and II in human lung squamous cell carcinoma NCI-H520 cells. Eur J Cancer Prev. 2017 Jul;26(4):314-323. [3]. Jin YH, et al. 2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells. Int J Mol Med. 2017 Jan;39(1):191-198.
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