ACTH (1-13) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) (Synonyms: SYSMEHFRWGKPV-OH) |
| カタログ番号GC45372 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ACTH (1-13) is a peptide fragment of adrenocorticotropic hormone , a peptide hormone found in the brain that is involved in the biological stress response.1 An acetylated form of ACTH (1-13), α-melanocyte stimulating hormone (α-MSH), is formed in the intermediate lobe of the pituitary gland by cleavage of ACTH (1-39), as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1,2 ACTH (1-13) is an agonist of melanocortin receptor 3 (MC3R) and MC4R, inducing cAMP production in vitro with EC50 values of 0.18 and 19 nM, respectively, which is similar in potency to that of α-MSH.3 It induces differentiation of melanocytes when used at concentrations ranging from 0.001 to 1,000 nM.4 ACTH (1-13) (40 and 400 pmol, i.c.v.) decreases food intake in broiler chicks.5
References
1. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev. Neurosci. 4(4), 321-363 (1993).
2. Catania, A., Airaghi, L., Colombo, G., et al. α-melanocyte-stimulating hormone in normal human physiology and disease states. Trends Endocrinol. Metab. 11(8), 304-308 (2000).
3. Miwa, H., Gantz, I., Konda, Y., et al. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors. J. Pharmacol. Exp. Ther. 273(1), 367-372 (1995).
4. Hirobe, T., and Hiroyuki, A. ACTH4-12 is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J. Exp. Zool. 286(6), 632-640 (2000).
5. Saneyasu, T., Honda, K., Kamisoyama, H., et al. Alpha-melanocyte stimulating hormone plays an important role in the regulation of food intake by the central melanocortin system in chicks. Peptides 32(5), 996-1000 (2011).
| Cas No. | SDF | ||
| 同義語 | SYSMEHFRWGKPV-OH | ||
| Canonical SMILES | O=C1[C@@]2(C)[C@@]([C@H]3C[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4(O)CC[C@@]5(O)[C@@](C)(O)[C@@]6([H])CC(C)=C(C)C(O6)=O)(O3)[C@@H](O)C=C1 | ||
| Formula | C75H106N20O19S.XCF3COOH | M.Wt | 1623.8 |
| 溶解度 | DMF: .2mg/mL,DMSO: 10mg/mL,Ethanol: slightly soluble,PBS (pH 7.2): 10mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.6158 mL | 3.0792 mL | 6.1584 mL |
| 5 mM | 0.1232 mL | 0.6158 mL | 1.2317 mL |
| 10 mM | 0.0616 mL | 0.3079 mL | 0.6158 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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