ACTH (1-39) (trifluoroacetate salt) (Synonyms: Adrenocorticotropic Hormone (1-39)) |
| カタログ番号GC45375 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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ACTH (1-39) is a potent agonist of melanocortin receptor 2 (MC2R) with an EC50 value of 57 pM in HeLa cells expressing the mouse receptor.1 It induces accumulation of cAMP and release of corticosterone from rat adrenal cells in a concentration-dependent manner.2 ACTH (1-39) also protects neurons from death induced by staurosporine , glutamate, NMDA , AMPA , kainate, quinolinic acid , and reactive oxygen species when used at a concentration of 400 nM.3 Formulations containing ACTH (1-39) have been used in the treatment of systemic lupus erythematosus.
References
1. Kapas, S., Cammas, F.M., Hinson, J.P., et al. Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137(8), 3291-3294 (1996).
2. Bristow, A.F., Gleed, C., FauchÈre, J.L., et al. Effects of ACTH (corticotropin) analogues on steroidogenesis and cyclic AMP in rat adrenocortical cells. Evidence for two different steroidogenically responsive receptors. Biochem J. 186(2), 599-603 (1980).
3. Lisak, R.P., Nedelkoska, L., Bealmear, B., et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp. Neurol. 273, 161-167 (2015).
| Cas No. | SDF | ||
| 同義語 | Adrenocorticotropic Hormone (1-39) | ||
| Canonical SMILES | OCCCCCCCCCCCCCCCCCCCCCCCCCCC(OC)=O | ||
| Formula | C207H308N56O58S.XCF3COOH | M.Wt | 4541.1 |
| 溶解度 | Formic Acid: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.2202 mL | 1.1011 mL | 2.2021 mL |
| 5 mM | 0.044 mL | 0.2202 mL | 0.4404 mL |
| 10 mM | 0.022 mL | 0.1101 mL | 0.2202 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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