Gentisein (Synonyms: NSC 329491) |
| カタログ番号GC49106 |
マンギフェリンの主要な代謝産物であるゲンチセイン (NSC 329491) は、4.7 μM の IC50 値で最も強力なセロトニン取り込み阻害を示します。
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Cas No.: 529-49-7
Sample solution is provided at 25 µL, 10mM.
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Gentisein is a xanthone that has been found in H. annulatum and has diverse biological activities.1,2,3 It scavenges DPPH radicals and inhibits the activity of α-glucosidase in cell-free assays (IC50s = 23.3 and 14.7 µM, respectively).1,2 Gentisein is cytotoxic against K562 chronic multiple leukemia cells, drug-sensitive HL-60 acute promyelocyte leukemia cells, and multidrug-resistant HL-60/DOX cells (IC50s = 102, 90.9, and 88.3 µM, respectively).3
1.Zhong, F.-F., Chen, Y., and Yang, G.-Z.Prenylated xanthones from the bark of Garcinia xanthochymus and their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activitiesMolecules15(10)7438-7449(2008) 2.Liu, Y., Zou, L., Ma, L., et al.Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitorsBioorg. Med. Chem.14(16)5683-5690(2006) 3.Biljali, S., Nedialkov, P., Zheleva-Dimitrova, D., et al.Cytotoxic effects and multidrug resistance modulation by five benzophenones and a xanthone Isolated from Hypericum annulatum Moris SUBSP. AnnulatumBiotechnol. Biotechnol. Equip.27(1)3561-3568(2014)
| Cas No. | 529-49-7 | SDF | |
| 同義語 | NSC 329491 | ||
| Canonical SMILES | O=C1C2=CC(O)=CC=C2OC3=CC(O)=CC(O)=C13 | ||
| Formula | C13H8O5 | M.Wt | 244.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml,Ethanol: 20 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.095 mL | 20.475 mL | 40.95 mL |
| 5 mM | 0.819 mL | 4.095 mL | 8.19 mL |
| 10 mM | 0.4095 mL | 2.0475 mL | 4.095 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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