GNF-6231 |
| カタログ番号GC32877 |
GNF-6231 は、Wnt シグナル伝達をブロックする、強力で選択的な経口投与可能なヤマアラシ阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1243245-18-2
Sample solution is provided at 25 µL, 10mM.
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GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration.3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg.4) GNF-6231 showed very robust dose-related antitumor efficacy.
[1]. Cheng D et al. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. ACS Med Chem Lett. 2016 May 10;7(7):676-80.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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