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GS-441524 tris-isobutyryl ester (Synonyms: GS-441524 tris-isobutyryl ester)

カタログ番号GC49165

GS-441524のプロドラッグ形態

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GS-441524 tris-isobutyryl ester 化学構造

Cas No.: 2563617-99-0

サイズ 価格 在庫数 個数
500 µg
$101.00
在庫あり
1 mg
$181.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of GS-441524 tris-isobutyryl ester

GS-441524 tris-isobutyryl ester is a prodrug form of the antiviral nucleoside analog and remdesivir metabolite GS-441524 .1 It reduces the cytopathic effect of respiratory syncytial virus (RSV) in infected HEp-2 cells with an EC50 value of 0.26 µM.

1.Mackman, R.L., Hui, H.C., Perron, M., et al.Prodrugs of a 1’-CN-4-aza-7,9-dideazaadenosine C-nucleoside leading to the discovery of remdesivir (GS-5734) as a potent inhibitor of respiratory syncytial virus with efficacy in the african green monkey model of RSVJ. Med. Chem.64(8)5001-5017(2021)

Chemical Properties of GS-441524 tris-isobutyryl ester

Cas No. 2563617-99-0 SDF
同義語 GS-441524 tris-isobutyryl ester
Canonical SMILES O=C(C(C)C)OC[C@@H]1[C@@H](OC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@@](C#N)(C2=CC=C3N2N=CN=C3N)O1
Formula C24H31N5O7 M.Wt 501.5
溶解度 DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of GS-441524 tris-isobutyryl ester

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.994 mL 9.9701 mL 19.9402 mL
5 mM 0.3988 mL 1.994 mL 3.988 mL
10 mM 0.1994 mL 0.997 mL 1.994 mL
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In vivo Formulation Calculator (Clear solution) of GS-441524 tris-isobutyryl ester

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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