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GSK-J2 (sodium salt)

カタログ番号GC43792

ヒストンH3リシン27(H3K27)デメチラーゼJMJD3は、細胞分化、発達、炎症反応、およびがんの転写調節に重要な役割を果たしています。

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GSK-J2 (sodium salt) 化学構造

Cas No.: 2108665-15-0

サイズ 価格 在庫数 個数
1mg
$47.00
在庫あり
5mg
$180.00
在庫あり
10mg
$312.00
在庫あり
50mg
$1,318.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

ヒストンH3リシン27(H3K27)デメチラーゼJMJD3は、細胞分化、発達、炎症反応、およびがんの転写調節に重要な役割を果たしています。GSK-J2はGSK-J1のピリジンレジオ異性体であり、JMJD3を弱く阻害します(IC50> 100μM)、これによりin vitro研究においてGSK-J1の適切な陰性対照となります。in vivo研究では、細胞浸透性プロドラッグ形態のGSK-J1およびGSK-J2がそれぞれGSK-J4およびGSK-J5として利用可能です。詳細についてはStructural Genomics Consortium(SGC)ウェブサイトを参照してください。

Chemical Properties

Cas No. 2108665-15-0 SDF
Canonical SMILES OC(CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CN=C4)=N1)=O.[Na]
Formula C22H23N5O2•Na M.Wt 412.4
溶解度 Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4248 mL 12.1242 mL 24.2483 mL
5 mM 0.485 mL 2.4248 mL 4.8497 mL
10 mM 0.2425 mL 1.2124 mL 2.4248 mL
  • モルアリティ計算機

  • 希釈計算機

質量
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濃度
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**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

Review for GSK-J2 (sodium salt)

Average Rating: 5 ★★★★★ (Based on Reviews and 20 reference(s) in Google Scholar.)

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